Biventricular Repair of Univentricular Heart Lowers Risk of Liver Disease Compared With the Fontan Operation
Authors' conclusion
Among a contemporary cohort of patients with single ventricle anatomy, BiV provide comparable long-term survival and lower risk of liver disease when compared to patients who have undergoing Fontan operations.
Study context
- Population
- Patients with univentricular physiology, Boston Children's Hospital, 2007–2022matched 258 per group
- Participants
- 927 patients
- Exposure
- Biventricular conversion vs destination Fontan operation
- BiVn = 341
- Fontann = 586reference
- Outcome
- Modified MACE, liver dysfunction, renal dysfunction and transplant-free survival
- Follow-up
- 10 years
Methodological detailspropensity-matched, single-centre
- Propensity-matched
- Single-centre
Main finding
As reported in the abstract
Estimated 10-year freedom from liver disease
P = 0.02
- No difference in 10-year freedom from major adverse cardiovascular events (MACE)
- P = 0.70
- No difference in transplant-free survival
- P = 0.70
- No difference in freedom from renal disease
- P = 0.60
Observational data: associations, not effects.
Further findings
Surgical interventions (incidence rate per 100 person-years)
P < 0.001
Readmissions (incidence rate per 100 person-years)
P = 0.002
Catheter-based interventions (incidence rate per 100 person-years)
P < 0.001
Original publication
Biventricular Repair of Univentricular Heart Lowers Risk of Liver Disease Compared With the Fontan Operation. JACC Adv. Published 17 December 2024. doi:10.
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