Arrhythmias & electrophysiology
Mental Disorders Following Implantable Cardioverter-Defibrillator Therapy: Incidence and Prognostic Implications in a Nationwide Cohort Study
Main finding · Newly diagnosed mental disordersResult — go to the resultHazard ratio 1.21 95% CI 1.14–1.29Study context
- Population
- Patients with implantable cardioverter-defibrillator (ICD) implantation vs matched controls, Korea, 2010–2020matched cohort
- Participants
- 6,356 vs 17,664
- Exposure
- ICD vs matched non-ICD controls
- ICDn = 6,356
- Matched controlsn = 17,664reference
- Outcome
- Cumulative incidence of newly diagnosed mental disorders
- Follow-up
- 10 years
Methodological detailspropensity-score matched, Korean National Health Insurance Service database
- Propensity-score matched
- Korean National Health Insurance Service database
Main finding
Newly diagnosed mental disorders
Hazard ratio
1.21
95% CI 1.14–1.29
By group
ICDvs Matched controls
HR 1.21 (95% CI 1.14–1.29)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Long-term prognosis in ICD patients, with vs without new mental disordersMental disordersvs No mental disordersAll-cause mortality | 2.00 (1.76–2.28) | |
| Long-term prognosis in ICD patients, with vs without new mental disordersMental disordersvs No mental disordersCardiac mortality | 1.83 (1.53–2.18) | |
| Long-term prognosis in ICD patients, with vs without new mental disordersMental disordersvs No mental disordersSevere HF events | 2.12 (1.54–2.93) | |
| Long-term prognosis in ICD patients, with vs without new mental disordersMental disordersvs No mental disordersAny-cause readmissions | 1.65 (1.50–1.82) | |
| 0.20.5125Hazard ratio (log scale) |
- Long-term prognosis in ICD patients, with vs without new mental disorders — Adverse effect on mortality more pronounced with AF than without AF
- Pinteraction = 0.04
- Long-term prognosis in ICD patients, with vs without new mental disorders: interaction P = 0.04
Most frequent mental disorders (ICD)
- Depressive disorder
- 18.4%
- Insomnia
- 16.8%
- Anxiety disorder
- 5.8%
Long-term prognosis in ICD patients, with vs without new mental disorders
- Schizophrenia spectrum disorders and early-diagnosed mental disorders (within 2.8 years) strongly associated with worse outcomes
Original publication
Mental Disorders Following Implantable Cardioverter-Defibrillator Therapy: Incidence and Prognostic Implications in a Nationwide Cohort Study. JACC Clin Electrophysiol. Published 24 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →