Long-Term Cardiovascular Health Trajectories Associated With Cardiovascular Disease and Mortality in Older Adults
Authors' conclusion
Maintaining a high CVH or improving CVH over time was associated with lower CVD risk and longer lifespan.
Study context
- Population
- Framingham Heart Study Offspring participants; Cardiovascular health (CVH) by Life's Essential 8 (LE8) from young adulthood to middle age (to age 60 years)
- Participants
- 3,364 participants
- Exposure
- LE8 CVH trajectory groups
- Outcome
- Incident CVD and all-cause mortality
- Follow-up
- After age 60 years
Methodological detailsFramingham Heart Study Offspring cohort, trajectory analysis
- Framingham Heart Study Offspring cohort
- Trajectory analysis
Main finding
As reported in the abstract
- Improved · cardiovascular disease (CVD)
- HR 0.52; P = 2.55e-7
- Stable high · CVD
- HR 0.69; P = 0.002
- Rapid decline · CVD
- HR 1.13; P = 0.5
- Improved · mortality
- HR 0.67; P = 7.05e-5
- Stable high · mortality
- HR 0.81; P = 0.03
- Rapid decline · mortality
- HR 1.51; P = 0.007
Observational data: associations, not effects.
Further findings
CVD risk by CVD polygenic risk score within LE8 trajectory groups
- Low or high polygenic risk score had similar CVD risk in each LE8 trajectory group
LE8 improvement over 12-year follow-up (from ages 60-65 years)
- Associated with lower incident CVD risk and all-cause mortality
Original publication
Long-Term Cardiovascular Health Trajectories Associated With Cardiovascular Disease and Mortality in Older Adults. JACC Adv. Published 31 December 2025. doi:10.
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