Variability in Lipid Profiles During Young Adulthood and the Risk of Coronary Artery Calcium Incidence in Midlife: Insights From the CARDIA Study
Authors' conclusion
Elevated variability in LDL-C and non-HDL-C during young adulthood was associated with an increased risk of CAC incidence in midlife, especially among those with high mean levels of atherogenic lipoproteins.
Study context
- Population
- CARDIA participants with initial coronary artery calcium (CAC) =0 (41.6% men; mean±SD age 40.2±3.6 years)
- Participants
- 2,395 participants
- Exposure
- Higher vs lower lipid variability (VIM, per 1-SD increment) and mean lipid levels in young adulthood
- Outcome
- CAC incidence (CAC >0 at follow-up)
- Follow-up
- Mean 9.0 years
Main finding
As reported in the abstract
CAC incidence per 1-SD increment of lipid variability (VIM)
Hazard ratio (95% CI)P value
LDL-C variability (per 1-SD)
1.139(1.048–1.238)
P = 0.002Non-HDL-C variability (per 1-SD)
1.102(1.014–1.198)
P = 0.022TG variability (per 1-SD)
1.480(1.384–1.582)
P < 0.001Per 1-SD, as printed
- CAC incidence
- 534 individuals (22.3%)
Observational data: associations, not effects.
Further findings
CAC incidence by elevated low-density lipoprotein cholesterol (LDL-C) variability, even in low mean levels of LDL-C (combination analysis)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Elevated variability of LDL-CEven in low mean levels of LDL-C · robust across sensitivity and subgroup analyses | 1.396 (1.106–1.763) | P = 0.005 | |
| 0.512Hazard ratio (log scale) |
- Both high lipid levels and high variability (LDL-C and non-HDL-C): greatest risk of CAC incidence
- Higher mean levels of total cholesterol, LDL-C and non-HDL-C associated with greater risk of CAC incidence
Original publication
Variability in Lipid Profiles During Young Adulthood and the Risk of Coronary Artery Calcium Incidence in Midlife: Insights From the CARDIA Study. Circ Cardiovasc Imaging. Published 13 September 2024. doi:10.
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