Cardiac sarcoidosis: new insights beyond the granuloma using spatial proteomics
Authors' conclusion
Spatial proteomics revealed novel features of the CS microenvironment and identified a distinct immune signature in tissue lacking overt inflammation.
Study context
- Population
- Archival cardiac tissues from patients with and without cardiac sarcoidosis
- Participants
- 64 participants
- Comparison
- Cardiac sarcoidosis vs Controls
- Cardiac sarcoidosis (CS)n = 39
- Controlsn = 25reference
- Outcome
- Immunologic, fibrotic and metabolic landscape of CS (spatial proteomics)
Methodological detailshigh-plex spatial protein analysis, mixed-effects modeling, GeoMx Digital Spatial Profiler; 79-protein panel; Regions of interest (ROIs) with and without granulomatous inflammation, divided into myocyte, stroma and vessel areas
- High-plex spatial protein analysis
- Mixed-effects modeling
- GeoMx Digital Spatial Profiler; 79-protein panel; ROIs with and without granulomatous inflammation, divided into myocyte, stroma and vessel areas
Main finding
As reported in the abstract
Seven-protein model accuracy, inflammation-free CS ROIs vs Controls
95.9%
Seven-protein model AUC, inflammation-free CS ROIs vs Controls
0.993
Original publication
Cardiac sarcoidosis: new insights beyond the granuloma using spatial proteomics. Eur Heart J. Published 23 December 2025. doi:10.
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