Cardiac Surgery-Specific Subtle Perioperative Serum Creatinine Change in Defining Acute Kidney Injury After Coronary Surgery
Authors' conclusion
A cardiac surgery-specific ΔSCr threshold in defining AKI was notably higher compared with the current general AKI definition.
Study context
- Population
- Patients undergoing coronary surgery, 10-year cohort with serial perioperative SCr
- Participants
- 37,706 patients
- Exposure
- Cardiac surgery-specific 48-h ΔSCr threshold vs KDIGO AKI criteria
- Outcome
- Prognostically significant 48-hour absolute ΔSCr threshold for 30-day mortality
- Follow-up
- 30 days
Main finding
As reported in the abstract
48-hour ΔSCr threshold for 30-day mortality
Threshold associated with adjusted OR ≥1.00 for 30-day mortality
0.549 mg/dL
Threshold by Youden index cutoff
0.553 mg/dL
Observational data: associations, not effects.
Further findings
AKI incidence
Stage-1 AKI KDIGO 18,835, 49.9% · New threshold 17.2%
Stage-1 solely from absolute criterion KDIGO 75.2%
Stage-1 solely from new criterion New threshold 27.7%
Prognostic value of AKI definition
- Prognostic value of new threshold significantly higher than KDIGO criteria
Original publication
Cardiac Surgery-Specific Subtle Perioperative Serum Creatinine Change in Defining Acute Kidney Injury After Coronary Surgery. JACC Adv. Published 15 October 2024. doi:10.
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