Heart failure & cardiomyopathies
Cardiomyopathy in First-Degree Relatives of Patients Presenting With Acute Myocarditis: Prevalence and Prognostic Significance
Authors' conclusion
Acute myocarditis aggregates with DCM within families, where it carries a worsened prognosis.
Study context
- Population
- Unselected patients hospitalised with acute myocarditis in Denmark and their first-degree relativesmedian age 49.8 years
- Participants
- 3,176 vs 31,760
- Exposure
- Patients with acute myocarditis vs matched controls from the general population
- Myocarditisn = 3,176
- Controlsn = 31,760reference
- Outcome
- Prevalence and long-term prognosis of DCM and HF in patients and first-degree relatives
Methodological detailsnationwide registries, age- and sex-matched (1:10)
- Nationwide registries
- Age- and sex-matched (1:10)
Main finding
As reported in the abstract
Familial DCM/HF (siblings) · baseline
Myocarditis
- Sibling with dilated cardiomyopathy (DCM)
- 12 [0.4%]
- Sibling with heart failure (HF)
- 36 [1.1%]
Controls
- Sibling with DCM
- 17 [0.05%]
- Sibling with HF
- 89 [0.3%]
Sibling with dilated cardiomyopathy (DCM)
Myocarditis12 [0.4%]
Controls17 [0.05%]
Sibling with heart failure (HF)
Myocarditis36 [1.1%]
Controls89 [0.3%]
Myocarditis vs ControlsOdds ratio (CI)P value
Sibling DCM
7.09(3.38–14.85)
P < 0.0001Sibling HF
2.92(1.25–6.80)
P < 0.0001Observational data: associations, not effects.
Further findings
Long-term mortality with a first-degree relative with DCM or HF (vs none)
| HR (CI) | ||
|---|---|---|
| Relative with DCM or HF (Myocarditis)Among Myocarditis | 1.40 (1.11–1.77) | |
| Relative with DCM or HF (Controls)Among Controls | 0.90 (0.81–1.01) | |
| 0.512Hazard ratio (log scale) |
| Outcome | Myocarditis | Controls |
|---|---|---|
| DCM and HF at baseline | ||
| DCM | 7 [0.2%] | 8 [0.0%] |
| HF | 336 [10.6%] | 695 [2.2%] |
| 20-year incidence of DCM, HF and all-cause mortality | ||
| DCM | 0.5% [0.3%-0.9%] | 0.06% [0.03%-0.11%] |
| HF | 15% [13%-17%] | 6.8% [6.4%-7.3%] |
| All-cause mortality | 47% [44%-50%] | 34% [33%-35%] |
- DCM and HF at baseline: P<0.0001 for both
- 20-year incidence of DCM, HF and all-cause mortality: P<0.0001
- Long-term mortality with a first-degree relative with DCM or HF (vs none): Pdifference=0.0008
Original publication
Cardiomyopathy in First-Degree Relatives of Patients Presenting With Acute Myocarditis: Prevalence and Prognostic Significance. Circ Heart Fail. Published 30 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →