Cardiovascular Involvement in Tuberculosis Patients Treated in Southern Africa
Authors' conclusion
Cardiac involvement is frequent in newly diagnosed TB patients. Early pericardial changes may be reversed with anti-TB treatment.
Study context
- Population
- HIV-positive and HIV-negative patients with pulmonary tuberculosis (TB), Zambia and South Africa, October 2022–November 2023
- Participants
- 286 vs 105
- Exposure
- At TB diagnosis vs after 6 months of anti-TB treatment
- At TB diagnosisn = 286reference
- After TB treatmentn = 105
- Outcome
- Prevalence of cardiovascular involvement (pericardial effusion, thickening, calcification, signs of constriction) on TTE
- Follow-up
- TB diagnosis
Methodological details2 tertiary care hospitals, cross-sectional and longitudinal analyses
- 2 tertiary care hospitals
- Cross-sectional and longitudinal analyses
Main finding
As reported in the abstract
Pericardial involvement at TB diagnosis
| Group | Pericardial effusion | Thickening | Calcification | Signs of constriction | Definite constriction |
|---|---|---|---|---|---|
| At TB diagnosis | 134 (47%) | 86 (30%) | 7 (2%) | 103 (42%) | 13 (12%) |
At TB diagnosis
Pericardial effusion134 (47%)
Thickening86 (30%)
Calcification7 (2%)
Signs of constriction103 (42%)
Definite constriction13 (12%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Pericardial changes after TB treatment vs at diagnosis · after 6 months of anti-TB treatmentAt TB diagnosis vs After TB treatment · pericardial effusion 47% vs 16% | P < 0.001 |
| Pericardial changes after TB treatment vs at diagnosis · after 6 months of anti-TB treatmentAt TB diagnosis vs After TB treatment · pericardial thickening 30% vs 15% | P = 0.002 |
| Pericardial changes after TB treatment vs at diagnosis · after 6 months of anti-TB treatmentAt TB diagnosis vs After TB treatment · calcification 2% vs 1% | P = 0.4 |
| Pericardial changes after TB treatment vs at diagnosis · after 6 months of anti-TB treatmentAt TB diagnosis vs After TB treatment · signs of constriction 42% vs 38% | P = 0.4 |
| Pericardial changes after TB treatment vs at diagnosis · after 6 months of anti-TB treatmentAt TB diagnosis vs After TB treatment · definite constriction 12% vs 14% | P = 0.8 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Cardiovascular Involvement in Tuberculosis Patients Treated in Southern Africa. JACC Adv. Published 5 December 2024. doi:10.
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