Arrhythmias & electrophysiology
Catheter ablation of atrial fibrillation in patients with heart failure: a trial-level meta-analysis
Pooled result · All-cause mortalityResult — go to the resultHazard ratio 0.58 95% CI 0.44–0.76Authors' conclusion
For a selected group of patients with chronic HF and AF enrolled in un-blinded RCTs, catheter ablation improved cardiac function, wellbeing and outcomes, including all-cause mortality.
Study context
- Population
- Patients with heart failure (HF) and atrial fibrillation (AF)
- Participants
- 2,490 patients13 randomised controlled trials (RCTs)
- Comparison
- Catheter ablation vs guideline-recommended pharmacological therapy (GRPT) alone
- Outcome
- All-cause mortality
Methodological detailsun-blinded RCTs
- Un-blinded RCTs
Pooled result
As reported in the abstract
Hazard ratio
0.58
95% CI 0.44–0.76
Catheter ablationvs GRPT
HR 0.58 (95% CI 0.44–0.76)
Further pooled results
| Outcome | MD (points) (95% CI) | |
|---|---|---|
| MLWHFQ score | −12 (−18 points to −6 points) | |
| −20−10010Difference, points (linear scale) |
| Outcome | Estimate |
|---|---|
| LVEF | MD +6 % (95% CI +4% to +9%) |
| 6-MWDTrend | MD +18 meters (95% CI −1 meter to +38 meters) |
Original publication
Catheter ablation of atrial fibrillation in patients with heart failure: a trial-level meta-analysis. Eur J Heart Fail. Published 16 July 2026. doi:10.
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