Arrhythmias & electrophysiology
How robust are recommended waiting times to pacing after cardiac surgery that are derived from observational data?
Authors' conclusion
When commonly used automated statistical methods are applied to observational data with the aim of defining the optimal time to pacing after cardiac surgery, the suggested answer is likely to be similar to the average time to pacing in that cohort.
Study context
- Population
- Bradycardic patients after cardiac surgery requiring permanent pacemaker (PPM)
- Participants
- 5,849 operations
- Outcome
- Optimal waiting time from surgery to PPM implant by ROC analysis (institutional cohort)
- Follow-up
- 30 days
Methodological detailssingle-centre
- Single-centre
Pooled result
As reported in the abstract
Optimal waiting time for predicting pacing dependence at 30 days (all patients)
12.5 days
AUC, pacing dependence at 30 days (all patients)
0.620
P = 0.031
AUC, regression of pacing dependence (pacing-dependent at implant)
0.769
P < 0.001
Systematic review: recommended optimal time points correlated with average implant time point
R = 0.96
P < 0.001
Further pooled results
Predictors of 30-day pacing dependence and of its regression
- Only pacing dependence at implant and time from surgery to implant associated with 30-day pacing dependence
- Only predictor of regression of pacing dependence was time from surgery to implant
Original publication
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