Heart failure & cardiomyopathies
Changes in Waiting Time, Need for Mechanical Circulatory Support and Outcomes in Paediatric Heart Transplant Recipients
Authors' conclusion
Early and long-term results after paediatric heart transplantation have been continuously improving over the past decades. Despite an increased demand for donor organs and the growing reliance on VAD as bridge to transplantation, post-transplantation survival is not compromised.
Study context
- Population
- Paediatric heart transplant recipients (<18 years), single institution, 1986 to 2022
- Participants
- 244 recipients
- Exposure
- Transplant eras: 1991-2000 vs 2001-2010 vs 2011-2020
- Outcome
- Survival
- Follow-up
- 1 year
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
1-year survival
P = 0.041
Observational data: associations, not effects.
Further findings
Median overall survival
Years
- Median overall survival
- 18.0
- Median conditional survival to 1 year post-transplant
- 20.9
Survival by age group
- Infants <1 year: higher early mortality; adolescents (11-17 years): increased long-term risks, possibly linked to adult donor characteristics
Waiting times
- Waiting times increased, especially for age groups 0-5 and 6-10 years
Pre-transplant ventricular assist devices (VAD) support
- Mechanical circulatory support (MCS) use, incl. VAD, surged; recipients in the most recent decade receiving pre-transplant VAD support
- 67%
Original publication
Changes in Waiting Time, Need for Mechanical Circulatory Support and Outcomes in Paediatric Heart Transplant Recipients. ESC Heart Fail. Published 14 July 2024. doi:10.
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