Arrhythmias & electrophysiologyCohort study
Implantable loop recorders in patients with Brugada syndrome: the BruLoop study
- Multicentre cohort study
- 18 international centres
Authors' conclusion
ILR detects arrhythmic events in nearly 30% of symptomatic BrS patients, leading to appropriate therapy in 70% of them. The most commonly detected arrhythmias are AAs and BAs, while VAs are detected only in 7% of cases.
Study context
- Population
- Patients with Brugada syndrome and implantable loop recorders (ILRs) (mean age 43.5 ± 15.9, 33.8% female, 74.1% symptomatic)
- Participants
- 370 patients · 18 international centres
- Outcome
- Diagnostic yield of continuous rhythm monitoring by ILR (arrhythmic events)
- Follow-up
- Median 3 years
Main finding
As reported in the abstract
Arrhythmic event recorded, symptomatic patients
Any arrhythmic event
30.7%
Atrial arrhythmias
18.6%
Bradyarrhythmias
10.2%
Ventricular arrhythmias
7.3%
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Independent predictors of arrhythmic events (multivariate analysis) — Presence of symptoms · multivariate analysis | 2.5 | P = 0.001 |
| Independent predictors of arrhythmic events (multivariate analysis) — Age >50 years · multivariate analysis | 1.7 | P = 0.016 |
| Predictor of VAs (multivariate analysis) · multivariate analysis | 9.0 | P < 0.001 |
Arrhythmic aetiology in patients with recurrent syncope
- Arrhythmic aetiology
- 22.4%
- Bradyarrhythmias (BAs) among arrhythmic causes
- 59.3%
- Ventricular arrhythmias (VAs) among arrhythmic causes
- 25.0%
- Atrial arrhythmias (AAs) among arrhythmic causes
- 15.6%
Therapy initiated after ILR findings
- Drug therapy initiation
- 11.4%
- Ablation procedure
- 10.9%
- Pacemaker implantation
- 2.5%
- Cardioverter-defibrillator implantation
- 8%
Original publication
Implantable loop recorders in patients with Brugada syndrome: the BruLoop study. Eur Heart J. Published 6 March 2024. doi:10.1093/eurheartj/ehae133
Summarised from the published abstract; every number is checked against it