Cohort study
Mitral valve prolapse: arrhythmic risk during pregnancy and postpartum
- Retrospective case series
- international
- multicentre
Authors' conclusion
The perinatal period could impose increased risk of malignant VA in women with high-risk AMVP.
Study context
- Population
- High-risk women with arrhythmic mitral valve prolapse (AMVP) who experienced malignant ventricular arrhythmia (VF, sustained VT or appropriate ICD shock) and at least one pregnancy
- Participants
- 18 women · 11 centres
- Exposure
- Perinatal period vs non-pregnancy period
- Outcome
- Incidence of malignant ventricular arrhythmia (VF, sustained VT or appropriate ICD shock)
Main finding
Malignant ventricular arrhythmia · 7.5 (IQR 5.8-16.6) years of follow-up
Univariate IRR
2.66
95% CI 1.23–5.76
Perinatal period vs Non-pregnancy period
univariate IRR 2.66 (95% CI 1.23–5.76)
As reported in the abstract
- Malignant ventricular arrhythmias (VAs) during follow-up
- 37
- Pregnancy-related malignant VAs
- 18
- Patients with pregnancy-related malignant VA
- 13 (72%)
Observational data: associations, not effects.
Original publication
Mitral valve prolapse: arrhythmic risk during pregnancy and postpartum. Eur Heart J. Published 14 May 2024. doi:10.1093/eurheartj/ehae224
Summarised from the published abstract; every number is checked against it