Relationship between c oronary p l aque morphology of the left anter i or descending artery and 12 m onths clinic a l outcome: the CLIMA study
An erratum to this article was published (Eur Heart J, 14 Jan 2020 ↗)
Authors' conclusion
The simultaneous presence of four high-risk OCT plaque features was found to be associated with a higher risk of major coronary events.
Study context
- Population
- Patients undergoing optical coherence tomography (OCT) of the untreated proximal LAD during clinically indicated coronary angiogram, 2013–20161,776 lipid plaques
- Participants
- 1,003 patients
- Exposure
- High-risk OCT plaque features present vs absent
- Outcome
- Composite of:
- Cardiac death
- Target segment MI
- Follow-up
- 1 year
Methodological detailsmulticentre, 11 independent centres
- Multicentre
- 11 independent centres
Main finding
As reported in the abstract
Cardiac death or target segment MI at 1 year, and OCT plaque features as predictors
Hazard ratio (95% CI)
MLA <3.5 mm²plaque-level, 1776 lipid plaques
2.1(1.1–4.0)
FCT <75 µmplaque-level, 1776 lipid plaques
4.7(2.4–9.0)
Lipid arc circumferential extension >180°plaque-level, 1776 lipid plaques
2.4(1.2–4.8)
OCT-defined macrophagesplaque-level, 1776 lipid plaques
2.7(1.2–6.1)
Pre-specified combination of plaque featuresindependent predictor; simultaneous presence of the four OCT criteria in the same plaque
7.54(3.1–18.6)
- Pre-specified combination observed in patients experiencing the primary endpoint
- 18.9%
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Relationship between c oronary p l aque morphology of the left anter i or descending artery and 12 m onths clinic a l outcome: the CLIMA study. Eur Heart J. Published 6 August 2019. doi:10.
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