Coronary disease & ACSCohort study
Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults
- Retrospective cohort study
- single-centre
- matched controls
Authors' conclusion
In adults with AAOCA, concomitant obstructive coronary atherosclerotic disease is the primary determinant of adverse events.
Study context
- Population
- Consecutive adults with AAOCA identified through coronary CT angiography, Italian tertiary referral centre, September 2004 to September 2024of 17,454 coronary computed tomography angiography (CCTAs)
- Participants
- 173 adults
- Exposure
- AAOCA vs matched controls with normal coronary anatomy
- AAOCAn = 173
- Outcome
- All-cause mortality and MACE (nonfatal ACS, revascularization procedures, HF hospitalization)
- Follow-up
- Median 37-month (17 to 69 months)
Main finding
As reported in the abstract
All-cause mortality and MACE
- AAOCA vs Controls: P = 0.321
- AAOCA vs Controls: P = 0.392
- matched controls
Observational data: associations, not effects.
Further findings
Obstructive coronary atherosclerotic disease
- Obstructive coronary atherosclerotic disease present
- 36 patients (21%)
Inducible myocardial ischemia (patients with functional imaging)
- Myocardial ischemia detected in those who underwent functional imaging (n=62)
- 60%
AAOCA repair
- AAOCA repair performed; majority treated conservatively
- 9 patients (5%)
Predictors of events during follow-up
- Only obstructive coronary atherosclerotic disease associated with higher event rate; AAOCA subtype and ischemia were not
Original publication
Clinical and Prognostic Significance of Anomalous Origin of a Coronary Artery in Adults. Circulation. Published 25 September 2025. doi:10.1161/circulationaha.125.074198
Summarised from the published abstract; every number is checked against it