Heart failure & cardiomyopathies
Clinical and prognostic significance of central and obstructive apnoeas in patients with transthyretin cardiac amyloidosis
Authors' conclusion
Both CA and OA are highly prevalent, both at daytime and nighttime, in patients with ATTR-CA and are associated with higher mortality.
Study context
- Population
- Patients with ATTR-CA undergoing 24 h ambulatory cardiorespiratory monitoring (aged 77 ± 7 years, 91% males, 96% wild-type)
- Participants
- 142 patients
- Exposure
- Central apnoea (CA) vs obstructive apnoea (OA) vs normal breathing (NB)
- Outcome
- All-cause mortality
- Follow-up
- Median 2.3-year (1.4-3.3 years)
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
median 2.3 years
Hazard ratio (95% CI)P value
Nighttime AHI ≥30 events/h
2.37(1.07–5.23)
P = 0.033High-sensitivity troponin T
2.43(1.42–4.17)
P = 0.001- 24 h, daytime and nighttime apnoea-hypopnoea index (AHIs) higher in non-survivors vs survivors
- all P < 0.05
- Independent of prevalent apnoea type
- P = 0.64
Observational data: associations, not effects.
Further findings
Prevalence of breathing disorders (24 h; daytime; nighttime)
Daytime
Nighttime
Original publication
Clinical and prognostic significance of central and obstructive apnoeas in patients with transthyretin cardiac amyloidosis. Eur J Prev Cardiol. Published 23 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →