Heart failure & cardiomyopathies
Lifetime cumulative activity burden is associated with symptomatic heart failure and arrhythmic risk in patients with arrhythmogenic right ventricular cardiomyopathy: a retrospective cohort study
Authors' conclusion
This study demonstrates for the first time that cumulative physical activity as a continuous predictor variable is associated with symptomatic heart failure and arrhythmic risk in ARVC patients.
Study context
- Population
- Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC), 93 with definite ARVC93 definite ARVC
- Participants
- 124 patients
- Exposure
- Cumulative physical activity burden and clinical endpoints
- Outcome
- Symptomatic HF, sustained VT and ICD interventions, by cumulative overall activity burden (Cox regression)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Cumulative overall activity burden, continuous model (HR per 100 METh/week)
Per 100 METh/weekHazard ratio (95% CI)P value
Symptomatic HF
1.017(1.003–1.032)
P = 0.015Sustained VT
1.021(1.006–1.037)
P = 0.007ICD interventions
1.017(1.000–1.034)
P = 0.048Per 100 METh/week, as printed
Observational data: associations, not effects.
Further findings
Reported activity
Metabolic equivalent of task-hours (METh)/week
- Median overall activity
- 202.3
- Sports-related activity
- 38.7
Sports-related vs non-sports-related activity as predictor
- Consistent association for sports-related activity; no significant association for non-sports-related activity
Original publication
Lifetime cumulative activity burden is associated with symptomatic heart failure and arrhythmic risk in patients with arrhythmogenic right ventricular cardiomyopathy: a retrospective cohort study. Europace. Published 21 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →