Heart failure & cardiomyopathies
Clinical Characteristics and Prognosis of Patients with Isolated Cardiac Sarcoidosis: Insights from the ILLUMINATE-CS Study
Authors' conclusion
Patients with iCS had more impaired cardiovascular function at the time of diagnosis than those with sCS. However, iCS was not independently associated with poor prognosis after adjustment for prognostic factors.
Study context
- Population
- Patients with cardiac sarcoidosis diagnosed by the Japanese Circulation Society (JCS) guidelines
- Participants
- 475 patients
- Comparison
- Isolated cardiac sarcoidosis vs systemic cardiac sarcoidosis
- Isolated cardiac sarcoidosis (iCS)n = 119
- Primary endpoint
- All-cause death, HF hospitalisation or fatal ventricular arrhythmia events
- Follow-up
- Median 42.3 (IQR 22.8-72.5) months
Methodological detailsmulticentre, retrospective registry
- Multicentre
- Retrospective registry
Primary result
As reported in the abstract
iCS vs sCSEstimate (95% CI)P value
Unadjusted
HR 1.62(1.12–2.34)
P = 0.011Adjusted for other covariates
adjusted HR 1.27(0.86–1.88)
P = 0.226- Primary outcomes, all patients
- 141 (29.7%)
Further findings
Baseline characteristics
- iCS had higher prevalence of prior AF or HF hospitalisation, or lower LVEF, than systemic cardiac sarcoidosis (sCS)
Original publication
Clinical Characteristics and Prognosis of Patients with Isolated Cardiac Sarcoidosis: Insights from the ILLUMINATE-CS Study. Eur J Heart Fail. Published 3 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it