Heart failure & cardiomyopathies
Clinical Features, Genetic Findings, and Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy: Data From a Brazilian Cohort
Authors' conclusion
Our main results suggest that the presence and extension of low QRS voltage can be a risk predictor for HF-death/HTx in ARVC patients, regardless of the arrhythmic risk.
Study context
- Population
- Patients with definite arrhythmogenic right ventricular cardiomyopathy (ARVC), Brazilian cohort
- Participants
- 111 patients
- Outcome
- Life-threatening arrhythmic events (LTAE) and HF death or heart transplantation (HF-death/HTx)
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
5 years
- 5-year cumulative probability of LTAE
- 30%
- 5-year cumulative probability of heart failure (HF)-death/HTx
- 10%
- Predictor of HF-death/HTx: reduced RV EF
- HR 0.93; P=0.010
- Predictor of HF-death/HTx: HF symptoms
- HR 4.37; P=0.010
- Predictor of HF-death/HTx: epsilon wave
- HR 4.99; P=0.015
- Predictor of HF-death/HTx: number of leads with low QRS voltage (28% higher risk per additional lead)
- HR 1.28; P=0.001
- Predictor of LTAE: prior syncope
- HR 1.81; P=0.040
- Predictor of LTAE: number of leads with T wave inversion
- HR 1.17; P=0.039
- Predictor of LTAE: low QRS voltage (17% higher risk per additional lead)
- HR 1.12; P=0.021
- Predictor of LTAE: younger age
- HR 0.97; P=0.006
- Predictor of LTAE: prior ventricular arrhythmia/VF
- HR 2.45; P=0.012
Observational data: associations, not effects.
Further findings
HF-death/HTx in patients without ventricular arrhythmia before diagnosis (subgroup, n = 40)
- Number of leads with low QRS voltage independently associated with HF-death/HTx
- HR 1.68; P=0.023
Original publication
Clinical Features, Genetic Findings, and Risk Stratification in Arrhythmogenic Right Ventricular Cardiomyopathy: Data From a Brazilian Cohort. Circ Arrhythm Electrophysiol. Published 31 January 2023. doi:10.
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