Valvular & structural heart diseaseCohort study
Clinical Impact of Myocardium at Risk in Transcatheter Aortic Valve Implantation
- international multicenter registry
- propensity matching
Authors' conclusion
In patients with concomitant coronary artery disease and severe aortic stenosis, the residual myocardial risk significantly affects TAVI outcomes. In particular, a rBCIS-JS >4 is associated with higher rates of major adverse cardiac and cerebrovascular events at 2 years.
Study context
- Population
- Patients with coronary artery disease and severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI), stratified by residual myocardium at risk (British Cardiovascular Intervention Society Jeopardy Score (BCIS-JS)) after a planned coronary revascularizationpatients enrolled, 294 pairs of patients were selected by propensity matching and compared
- Participants
- 2,407 patients
- Exposure
- patients with residual BCIS-JS (rBCIS-JS) >4 compared with patients with rBCIS-JS ≤4
- Outcome
- Composite of:
- All-cause death
- Nonfatal myocardial infarction
- Nonfatal stroke
- Rehospitalization for heart failure
- Follow-up
- 2 years
Main finding
As reported in the abstract
P = 0.004
Observational data: associations, not effects.
Further findings
2-year major adverse cardiac and cerebrovascular events (multivariate analysis)
| Comparison | hazard ratio (95% CI) | P value | |
|---|---|---|---|
| rBCIS-JS >4 · independently predicted · multivariate analysis | 1.43 (1.11–1.84) | P = 0.005 | |
| 0.512Hazard ratio (log scale) |
Myocardial infarction · 2-year follow-up
- A significantly lower rate of myocardial infarction was reported in patients with BCIS-JS ≤4
- 8.2% versus 2.6%
- P =0.011
Original publication
Clinical Impact of Myocardium at Risk in Transcatheter Aortic Valve Implantation. Circ Cardiovasc Interv. Published 20 May 2026. doi:10.1161/circinterventions.125.015770
Summarised from the published abstract; every number is checked against it