Clinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older Adults
Main findingResult — go to the resultWeighted odds ratio 1.28 95% CI 1.18–1.39Authors' conclusion
The study's findings indicate that among hospitalized older adults with elevated BPs, intensive pharmacologic antihypertensive treatment was associated with a greater risk of adverse events.
Study context
- Population
- Patients aged ≥65 years hospitalized for noncardiovascular diagnoses with elevated blood pressure (BPs) in the first 48 hours, Veterans Health Administration, 2015–2017
- Participants
- 66,140 patients
- Exposure
- Early intensive inpatient BP treatment vs no intensive treatment
- Intensive treatmentn = 14,084
- Outcome
- Composite of:
- Inpatient mortality
- ICU transfer
- Stroke
- AKI
- B-type natriuretic peptide elevation
- Troponin elevation
- Follow-up
- In-hospital
Methodological detailspropensity score overlap weighting, Data analyzed between October 1, 2021, and January 10, 2023
- Propensity score overlap weighting
- Data analyzed between October 1, 2021, and January 10, 2023
Main finding
As reported in the abstract
Weighted odds ratio
1.28
95% CI 1.18–1.39
Events by group
Intensive treatmentvs No intensive treatment
weighted OR 1.28 (95% CI 1.18–1.39)
Observational data: associations, not effects.
Further findings
| Outcome | Weighted OR (95% CI) | |
|---|---|---|
| Primary composite, intravenous antihypertensives (subgroup)Intravenous antihypertensives | 1.90 (1.65–2.19) | |
| 0.512Weighted odds ratio (log scale) |
Additional antihypertensive doses during remainder of hospitalization
Components of the composite
- Intensively treated patients more likely to experience each component except stroke and mortality
Subgroups by age, frailty, preadmission BP, early hospitalization BP, CVD history
- Findings consistent across subgroups
Original publication
Clinical Outcomes of Intensive Inpatient Blood Pressure Management in Hospitalized Older Adults. JAMA Intern Med. Published 1 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →