Heart failure & cardiomyopathies
Clinical Phenotypes of Heart Failure Patients with Supranormal Ejection Fraction
Authors' conclusion
In a heterogeneous HFsnEF cohort, three clusters were identified by unsupervised HCPC with distinct clinical characteristics and outcomes.
Study context
- Population
- Hospitalised heart failure (HF) patients with LVEF ≥65% (HFsnEF)
- Participants
- 221 patients
- Exposure
- Cluster 1 vs Cluster 2 vs Cluster 3
- Outcome
- Phenotypic subgroups (clusters) of HFsnEF
Methodological detailshierarchical clustering on principal components (HCPC), decision tree modelling, consecutive hospitalised patients
- Hierarchical clustering on principal components (HCPC)
- Decision tree modelling
- Consecutive hospitalised patients
Main finding
As reported in the abstract
HFsnEF phenogroups
- Three mutually exclusive clusters identified
- 3
Observational data: associations, not effects.
Further findings
| Outcome | aHR | P value |
|---|---|---|
| All-cause mortality · median follow-up 53.4 monthsCluster 1 vs Cluster 2 | 3.32 | P = 0.022 |
| All-cause mortality · median follow-up 53.4 monthsCluster 1 vs Cluster 3 | 3.81 | P = 0.036 |
| All-cause mortality · median follow-up 53.4 monthsCluster 2 vs Cluster 3 | 1.15 | P = 0.865 |
| CV mortality · median follow-up 53.4 monthsCluster 1 vs Cluster 2 | 3.73 | P = 0.022 |
| CV mortality · median follow-up 53.4 monthsCluster 1 vs Cluster 3 | 4.27 | P = 0.020 |
| CV mortality · median follow-up 53.4 monthsCluster 2 vs Cluster 3 | 1.15 | P = 0.870 |
| CV readmission · median follow-up 53.4 monthsCluster 1 vs Cluster 2 · comparable among the three clusters | 0.82 | P = 0.590 |
| CV readmission · median follow-up 53.4 monthsCluster 1 vs Cluster 3 · comparable among the three clusters | 1.04 | P = 0.900 |
| CV readmission · median follow-up 53.4 monthsCluster 2 vs Cluster 3 · comparable among the three clusters | 1.28 | P = 0.580 |
- All-cause mortality — All-cause deaths, overall
- 46 (20.8%)
- Cardiovascular (CV) mortality — CV deaths, overall
- 39
- CV readmission — Patients with CV readmission, overall
- 70 (31.7%)
Original publication
Clinical Phenotypes of Heart Failure Patients with Supranormal Ejection Fraction. ESC Heart Fail. Published 12 August 2024. doi:10.
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