Comparing the outcomes of rheumatic heart disease in pregnancy complicated with and without atrial fibrillation: A propensity score matched analysis
Authors' conclusion
Atrial fibrillation in pregnancy among women with RHD was associated with an increased risk of maternal morbidity and mortality, with a trend towards an increase in some non-cardiac pregnancy complications compared to those pregnant women without AF.
Study context
- Population
- Pregnant women with rheumatic heart disease receiving care at one centre, 2011–202171 with atrial fibrillation (AF)
- Exposure
- RHD in pregnancy with AF vs without AF
- Outcome
- Composite adverse outcome:
- Maternal death
- HF
- Thromboembolic events
Methodological detailspropensity-score matched, single-centre
- Propensity-score matched
- Single-centre
Main finding
As reported in the abstract
Composite adverse outcome
P < 0.001
Observational data: associations, not effects.
Further findings
Maternal death
HF
P < 0.001
Non-cardiac pregnancy complications
Miscarriage
Small for gestational age Cases 16.3 · Controls 9.0%
Caesarean
| Outcome | Adjusted OR (CI) | |
|---|---|---|
| Adverse cardiac outcomes | 56.6 (14.1–226.8) | |
| 0.050.21520Adjusted odds ratio (log scale) |
Incidence of AF in pregnant women with RHD
- AF during pregnancy and childbirth
- 71 (5.1%; 95%CI 4.1%-6.4%)
- New-onset AF
- 34 (47.9%)
Non-cardiac pregnancy complications
- Most non-cardiac complications similar; trend towards higher miscarriage, SGA and caesarean with AF
Original publication
Comparing the outcomes of rheumatic heart disease in pregnancy complicated with and without atrial fibrillation: A propensity score matched analysis. Am Heart J. Published 16 April 2024. doi:10.
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