Arrhythmias & electrophysiology

Comparison of excess mortality between atrial fibrillation, heart failure, myocardial infarction, and stroke: trends over 2000–22

Eur J Prev CardiolPublished Nationwide cohort study

Authors' conclusion

AF was the condition or was among those with the smallest improvement in relative survival and AF and stroke showed the smallest improvement in 1-year excess mortality.

Study context

Population
All individuals newly diagnosed with atrial fibrillation (AF), heart failure (HF), myocardial infarction (MI) or stroke in Denmark, 2000–2021
Exposure
AF vs HF, MI and stroke
  • AFn = 364,199
  • HFn = 242,570
  • MIn = 172,552
  • Stroken = 281,407
Outcome
Trends in relative survival and excess mortality rates vs general population (adjusted for age, sex, calendar year)
Follow-up
1, 5 and 10 years after diagnosis
Methodological detailsgeneral Danish population as comparator
  • General Danish population as comparator

Main finding

As reported in the abstract

Average improvement in relative survival over calendar years
AF smallest average improvement at 1 year (per year)
0.35%
AF smallest average improvement at 5 years (per year)
0.58%
10 years: AF average improvement (per year; AF, MI, stroke smallest)
0.77%
10 years: MI average improvement (per year)
0.72%
10 years: stroke average improvement (per year)
0.80%

Observational data: associations, not effects.

Further findings

Average improvement in excess mortality rate over calendar years

1 year: AF (smallest, with stroke), additional deaths per 1000 person-years per year
−1.02
1 year: stroke, additional deaths per 1000 person-years per year
−0.96
5 years: MI smallest, additional deaths per 1000 person-years per year
−0.13
No average improvement in 10-year excess mortality rate for MI

Original publication

Comparison of excess mortality between atrial fibrillation, heart failure, myocardial infarction, and stroke: trends over 2000–22. Eur J Prev Cardiol. Published 25 June 2025. doi:10.1093/eurjpc/zwaf371

Composed by AI from the published abstract and checked against it. How Briefs are made →

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