Arrhythmias & electrophysiology
Comparison of hemolysis with different pulsed field ablation systems
Authors' conclusion
The degree of hemolysis may differ between the PFA systems. Further investigation might be necessary to determine the safe number of PFA applications for each PFA system.
Study context
- Population
- Patients who underwent pulsed field ablation (PFA) of atrial fibrillation, and patients who underwent cryoballoon ablation as a control
- Participants
- 38 / 38 / 14
- Comparison
- Differences in hemolysis between 2 PFA systems
- PulseSelectn = 38
- Farapulsen = 38
- Cryoballoon ablationn = 14
- Outcome
- Total number of applications
Methodological detailscryoballoon ablation control
- Cryoballoon ablation control
Main finding
As reported in the abstract
PulseSelect
53
median · range in brackets 50–58
Farapulse
53
median · range in brackets 46–60
P = 0.868
Further findings
| Outcome | PulseSelect | Farapulse |
|---|---|---|
| Free hemoglobin, before and after the procedure | ||
| Before | 0.01 (0.00-0.01) | 0.01 (0.01-0.02) |
| After | 0.03 (0.02-0.03) | 0.06 (0.05-0.06) |
- Hemolysis biomarkers (lactate dehydrogenase, total bilirubin, free hemoglobin) and low-level haptoglobin · within 24 hours · Farapulse vs PulseSelect
- P < 0.001
- Hemolysis biomarkers (lactate dehydrogenase, total bilirubin, free hemoglobin) and low-level haptoglobin: significantly higher hemolysis biomarkers and more patients with low-level haptoglobin with Farapulse
Hemolysis biomarkers, PulseSelect vs cryoballoon ablation
- No significant difference in the hemolysis biomarkers between PulseSelect and cryoballoon ablation
Myocardial injury biomarkers (creatine kinase)
- Significantly higher creatine kinase levels for both PulseSelect and Farapulse than cryoballoon; no differences between the 2 PFA systems
Original publication
Comparison of hemolysis with different pulsed field ablation systems. Heart Rhythm. Published 4 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →