Arrhythmias & electrophysiology
Comparison of in-hospital outcomes and complications of leadless pacemaker and traditional transvenous pacemaker implantation
Authors' conclusion
There is a higher likelihood of all-cause in-hospital mortality and complications following LPM implantation in comparison to TV-VVI.
Study context
- Population
- Adults undergoing leadless or single-chamber transvenous pacemaker implantation, US national inpatient database, 2016–2019expanded samples of admissions
- Participants
- 35,430 adults
- Exposure
- Leadless pacemakers (LPM) vs TV-VVI
- LPMn = 7,780
- TV-VVIn = 27,650reference
- Outcome
- Procedural complications and in-hospital outcomes
- Follow-up
- In-hospital
Methodological detailsnational inpatient database, multivariable logistic regression, 1:1 propensity score matching
- National inpatient database
- Multivariable logistic regression
- 1:1 propensity score matching
Main finding
As reported in the abstract
LPM vs TV-VVIAdjusted odds ratio (95% CI)P value
In-hospital mortality
1.63(1.29–2.05)
P < 0.001Vascular complications
7.54(3.21–17.68)
P < 0.001VTE
3.67(2.68–5.02)
P < 0.001Cardiac complications
1.79(1.59–2.03)
P < 0.001Device thrombus formation
5.03(2.55–9.92)
P < 0.001Blood transfusion
1.54(1.14–2.07)
P < 0.005Pulmonary complications (higher with TV-VVI)
0.68(0.54–0.87)
P < 0.002Device revisions (higher with TV-VVI)
0.42(0.23–0.76)
P < 0.004Observational data: associations, not effects.
Original publication
Comparison of in-hospital outcomes and complications of leadless pacemaker and traditional transvenous pacemaker implantation. Europace. Published 15 September 2023. doi:10.
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