Arrhythmias & electrophysiology
Conduction Velocity and Anisotropic Properties of Fibrillation Waves During Acutely Induced and Long-Standing Persistent Atrial Fibrillation (AF)
Authors' conclusion
Increasing AF complexity was associated with increased spatiotemporal variability of local CV vectors, local conduction heterogeneity, and anisotropy ratio.
Study context
- Population
- Right atrium epicardial mapping during acutely induced AF or long-standing persistent AF
- Participants
- 23 vs 25
- Comparison
- Long-standing persistent atrial fibrillation (LSPAF) vs acute atrial fibrillation (AAF)
- LSPAFn = 23
- AAFn = 25reference
- Outcome
- LDH and anisotropy ratio derived from local conduction velocities (CVs) during AF, as parameters to stage AF
Methodological detailsepicardial mapping, Episodes of 9 ± 4 seconds of AF analysed
- Epicardial mapping
- Episodes of 9 ± 4 seconds of AF analysed
Main finding
As reported in the abstract
| Group | CV | CV dispersion | CV temporal variability | Local directional heterogeneity (LDH) | Anisotropy ratio |
|---|---|---|---|---|---|
| AAF | 71.5 ± 6.8 cm/s | 1.59 ± 0.21 | 32.0 ± 4.7 cm/s | 19.6% ± 4.4% | 1.38 ± 0.07 |
| LSPAF | 67.6 ± 5.6 cm/s | 1.95 ± 0.17 | 38.5 ± 3.3 cm/s | 26.0% ± 3.4% | 1.51 ± 0.14 |
CV
AAF71.5 ± 6.8 cm/s
LSPAF67.6 ± 5.6 cm/s
CV dispersion
AAF1.59 ± 0.21
LSPAF1.95 ± 0.17
CV temporal variability
AAF32.0 ± 4.7 cm/s
LSPAF38.5 ± 3.3 cm/s
Local directional heterogeneity (LDH)
AAF19.6% ± 4.4%
LSPAF26.0% ± 3.4%
Anisotropy ratio
AAF1.38 ± 0.07
LSPAF1.51 ± 0.14
- LSPAF vs AAF: P = 0.037 — CV (slower conduction in LSPAF)
- LSPAF vs AAF: P < 0.001 — CV dispersion
- LSPAF vs AAF: P < 0.001 — CV temporal variability
- LSPAF vs AAF: P < 0.001 — LDH
- LSPAF vs AAF: P < 0.001 — anisotropy ratio
Further findings
LSPAF vs most complex AAF (type III)
- LSPAF still associated with larger CV dispersion, higher temporal variability of CV and larger amount of LDH
Original publication
Conduction Velocity and Anisotropic Properties of Fibrillation Waves During Acutely Induced and Long-Standing Persistent AF. JACC Clin Electrophysiol. Published 16 May 2024. doi:10.
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