Coronary Artery Bypass Graft Failure in Women: Incidence and Clinical Implications
Pooled result · MI and repeat revascularizationResult — go to the resultOdds ratio 3.94 95% CI 1.79–8.67Authors' conclusion
Graft failure is more frequent in women and is associated with adverse cardiac events. The excess mortality risk associated with female sex among CABG patients is not mediated by graft failure.
Study context
- Population
- CABG patients in RCTs with systematic imaging follow-up
- Participants
- 4,413 patients7 RCTs
- Comparison
- Women vs men after CABG
- Womenn = 777
- Outcome
- Association of graft failure with MI and repeat revascularization between CABG and imaging
Methodological detailssystematic imaging follow-up, mediation analysis
- Systematic imaging follow-up
- Mediation analysis
Pooled result
MI and repeat revascularization · median imaging follow-up 1.03 years
Odds ratio
3.94
95% CI 1.79–8.67
By group
Women
- Graft failure, patient level
- 37.3%
- Graft failure, graft level
- 20.5%
Men
- Graft failure, patient level
- 32.9%
- Graft failure, graft level
- 15.8%
Graft failure, patient level
Women37.3%
Men32.9%
Graft failure, graft level
Women20.5%
Men15.8%
Graft failurevs No graft failure
OR 3.94 (95% CI 1.79–8.67)
As reported in the abstract
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| Death after imaging, in womenGraft failurevs No graft failure | OR 3.18 (95% CI 1.73–5.85) | |
| Death: female sex, mediation by graft failureWomenvs MenDirect effect | HR 1.84 (95% CI 1.35–2.50) | |
| Death: female sex, mediation by graft failureWomenvs MenIndirect effect via graft failure | HR 1.04 (95% CI 0.86–1.26) | |
| 0.20.5125Ratio (log scale) |
Original publication
Coronary Artery Bypass Graft Failure in Women: Incidence and Clinical Implications. J Am Coll Cardiol. Published 9 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →