Coronary disease & ACSRandomised controlled trial
Percutaneous Coronary Intervention (PCI) of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery
- Randomised controlled trial
- multicentre
- 14 centres in Europe
- Long-term follow-up ongoing
Authors' conclusion
In the randomized PROCTOR trial, SVG PCI was associated with improved 1-year clinical outcomes compared with native vessel PCI, primarily driven by lower rates of PCI-related MI and clinically driven target coronary territory revascularization.
Study context
- Population
- Post-CABG patients with significant saphenous vein graft (SVG) stenosis/failure and a heart team-defined indication for revascularization
- Participants
- 220 patients
- Comparison
- Native vessel PCI vs SVG PCI
- Native vessel PCIn = 108
- SVG PCIn = 112reference
- Primary endpoint
- Major adverse cardiac events:
- All-cause mortality
- Nonfatal target coronary territory myocardial infarction (MI)
- Clinically driven target coronary territory revascularization
- Follow-up
- 1 year after index PCI
Primary result
Major adverse cardiac events · 1 year
Hazard ratio
2.14
95% CI 1.25–3.65
P = 0.006
Events by treatment group
Native vessel PCI vs SVG PCI
HR 2.14 (95% CI 1.25–3.65); P = 0.006
As reported in the abstract
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality · 1 year · no significant difference | 1.59 (0.45–5.64) | P = 0.472 | |
| Nonfatal target coronary territory MI · 1 year | 2.12 (1.08–4.17) | P = 0.029 | |
| Clinically driven target coronary territory revascularization · 1 year | 2.19 (1.02–4.72) | P = 0.044 | |
| 0.20.5125Hazard ratio (log scale) |
Safety
| Outcome | Native vessel PCI | SVG PCI | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| PCI-related MI | 13% | 1% | 14.85 (1.95–112.96) | P = 0.009 | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
PCI of Native Coronary Artery vs Saphenous Vein Graft After Prior Bypass Surgery. J Am Coll Cardiol. Published 28 October 2025. doi:10.1016/j.jacc.2025.09.1577
Summarised from the published abstract; every number is checked against it