Coronary Atherosclerosis Across the Glycemic Spectrum Among Asymptomatic Adults: The Miami Heart Study at Baptist Health South Florida
Authors' conclusion
Among asymptomatic adults, worse glycemic status is associated with higher prevalence and extent of coronary atherosclerosis, high-risk plaque, and stenosis. In diabetes, CAC was more closely associated with CCTA findings and informative in a larger population than the pooled cohort equations.
Study context
- Population
- Asymptomatic adults without atherosclerotic CVD, Miami Heart Study, undergoing coronary artery calcium (CAC) and coronary computed tomography angiography (CCTA) testing49.5% women
- Participants
- 2,352 adults
- Exposure
- Prediabetes and diabetes vs euglycemia
- Outcome
- Prevalence of coronary atherosclerosis by CCTA (any plaque, noncalcified plaque, plaque with ≥1 high-risk feature, maximal stenosis ≥50%)
Main finding
As reported in the abstract
Any coronary plaque
Each group vs euglycemiaOdds ratio (95% CI)
Prediabetes
1.30(1.05–1.60)
Diabetes
1.75(1.17–2.61)
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Noncalcified plaquePrediabetesvs EuglycemiaAdjusted | 1.47 (1.19–1.81) | |
| Noncalcified plaqueDiabetesvs EuglycemiaAdjusted | 1.99 (1.38–2.87) | |
| Plaque with ≥1 high-risk featurePrediabetesvs EuglycemiaAdjusted | 1.65 (1.14–2.39) | |
| Plaque with ≥1 high-risk featureDiabetesvs EuglycemiaAdjusted | 2.53 (1.48–4.33) | |
| Stenosis ≥50%Diabetesvs EuglycemiaAdjusted | 3.01 (1.79–5.08) | |
| 0.20.5125Odds ratio (log scale) |
Diabetes with estimated atherosclerotic CVD risk <5% (subgroup)
- Coronary plaque
- 46%
- Stenosis ≥50%
- 10%
Diabetes with CAC=0 (subgroup)
- Coronary plaque
- 30%
- Stenosis ≥50%
- 3%
Original publication
Coronary Atherosclerosis Across the Glycemic Spectrum Among Asymptomatic Adults: The Miami Heart Study at Baptist Health South Florida. Circ Cardiovasc Imaging. Published 29 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →