Coronary CTA-based vascular radiomics predicts atherosclerosis development proximal to LAD myocardial bridging
Authors' conclusion
The CCTA-based pMB CS vascular radiomics model can predict plaque development in LAD MB.
Study context
- Population
- Patients with repeated coronary computed tomography angiography (CCTA) showing LAD myocardial bridging without proximal plaque on index CCTAdevelopment n = 192
- Participants
- 295 patients
- Comparison
- pMB CS vascular radiomics model vs clinical and anatomical model
- Outcome
- Proximal plaque development of LAD MB in follow-up CCTA
Methodological detailsmulticentre, external validation
- Multicentre
- External validation
Performance
As reported in the abstract
Prediction of proximal plaque development
| Test or model | AUC (training, internal test, external) |
|---|---|
| pMB CS | 0.78, 0.75, 0.75 |
pMB CS
AUC (training, internal test, external)0.78, 0.75, 0.75
- pMB CS vs Clinical and anatomical model: P < 0.05 — higher AUC in all sets
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Clinical and anatomical model + pMB CS (external validation set)Clinical and anatomical model + pMB CS vs Clinical and anatomical model · from 0.56 to 0.75 | AUC 0.75 | P = 0.002 |
| Clinical and anatomical model + pMB CS (external validation set)Clinical and anatomical model + pMB CS vs Clinical and anatomical model | NRI 0.76 (CI 0.37–1.14) | P < 0.001 |
| Clinical and anatomical model + pMB CS (external validation set)Clinical and anatomical model + pMB CS vs Clinical and anatomical model | IDI 0.17 (CI 0.07–0.26) | P < 0.001 |
Original publication
Coronary CTA-based vascular radiomics predicts atherosclerosis development proximal to LAD myocardial bridging. Eur Heart J Cardiovasc Imaging. Published 23 May 2024. doi:10.
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