Heart failure & cardiomyopathies
Could echocardiographic left atrial characterization have additive value for detecting risks of atrial arrhythmias and stroke in patients with hypertrophic cardiomyopathy?
Main findingResult — go to the resultOdds ratio 0.42 95% CI 0.29–0.61Authors' conclusion
The decrease in PLAS was strongly associated with the risk of stroke, even in patients without any documented AA.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) undergoing transthoracic echocardiography
- Participants
- 216 patients
- Exposure
- Patients meeting vs not meeting the composite endpoint
- Composite endpointn = 78
- Outcome
- Composite of atrial arrhythmia (AA) and/or stroke and peripheral embolism
- Follow-up
- 2.9 years
Main finding
As reported in the abstract
Odds ratio
0.42
95% CI 0.29–0.61
P < 0.0001
By group
PLAS
OR 0.42 (95% CI 0.29–0.61); P < 0.0001
- Composite endpoint met
- 78 (36%)
Observational data: associations, not effects.
Further findings
Stroke without clinical atrial arrhythmia (AA)
- Stroke occurred in patients without any clinical AA
- 67%
Peak left atrial strain (PLAS) cut-off prediction
- PLAS <15.5%: specificity for event prediction
- 91%
- PLAS 15% cut-off: predictive value for new-onset AA
Original publication
Could echocardiographic left atrial characterization have additive value for detecting risks of atrial arrhythmias and stroke in patients with hypertrophic cardiomyopathy? Eur Heart J Cardiovasc Imaging. Published 6 July 2022. doi:10.
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