Heart failure & cardiomyopathies
Endogenous assessment of late gadolinium enhancement grey zone in patients with non-ischaemic cardiomyopathy with T1ρ and native T1 mapping
Authors' conclusion
T1ρ mapping is a feasible method to detect myocardial fibrosis in patients with non-ischaemic cardiomyopathy no matter the presence of LGE. Compared with native T1, T1ρ may serve as a better discriminator in the identification of LGE grey zone.
Study context
- Population
- Patients with non-ischaemic cardiomyopathy (hypertrophic cardiomyopathy (HCM), idiopathic dilated cardiomyopathy (DCM)) and healthy controls undergoing native T1 and T1ρ mapping
- Participants
- 27 / 16 / 18
- Exposure
- T1ρ mapping vs native T1 mapping for detecting myocardial fibrosis and late gadolinium enhancement (LGE) grey zone
- HCMn = 27
- DCMn = 16
- Healthy controlsn = 18reference
- Outcome
- Feasibility of T1ρ and native T1 mapping in detecting myocardial fibrosis, focusing on identification of LGE grey zone (2-6 SDs above remote myocardium)
Main finding
As reported in the abstract
- HCM and DCM: significantly higher native T1 and T1ρ values than controls regardless of LGE
- all P < 0.01
- Differences in native T1 and T1ρ among LGE core, grey zone, remote area and control myocardium
- P < 0.0001
- Grey zone T1ρ significantly higher than control
- P < 0.01
- Grey zone native T1 not significantly different from control
- P = 0.089
Observational data: associations, not effects.
Further findings
Correlation of T1ρ with native T1 and ECV
- T1ρ vs native T1: r = 0.54
- P < 0.001
- T1ρ vs ECV: r = 0.54
- P < 0.001
Original publication
Endogenous assessment of late gadolinium enhancement grey zone in patients with non-ischaemic cardiomyopathy with T1ρ and native T1 mapping. Eur Heart J Cardiovasc Imaging. Published 6 July 2022. doi:10.
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