Defining Demographic-specific Coronary Artery Calcium Percentiles in the Population Aged ≥75: The ARIC Study and MESA
Authors' conclusion
In community-dwelling adults aged ≥75 years free of clinical coronary heart disease, the prevalence of zero CAC was 11%, and CAC >100 as a threshold for high ASCVD risk would categorize most of this older population as high risk.
Study context
- Population
- Adults aged ≥75 years without clinical CHD
- Participants
- 2,886 adults
- Exposure
- ARIC vs MESA
- ARICn = 2,217
- MESAn = 669
- Outcome
- Distribution of CAC and demographic-specific CAC percentiles (prevalence of CAC >0; sex- and race-specific percentiles across age)
Methodological detailspooled cohorts (ARIC visit 7 and MESA visit 5), coronary artery calcium (CAC) percentiles estimated nonparametrically with locally weighted regression models and pooled residual ranking
- Pooled cohorts (ARIC visit 7 and MESA visit 5)
- CAC percentiles estimated nonparametrically with locally weighted regression models and pooled residual ranking
Main finding
As reported in the abstract
- Zero CAC, overall
- 11%
- Zero CAC, White males
- 4%
- Zero CAC, Black males
- 13%
- Zero CAC, White females
- 14%
- Zero CAC, Black females
- 18%
- CAC>100, all participants
- 62.5%
- CAC identified in participants aged ≥90 years across sex-race subgroups
- ≈95%
Observational data: associations, not effects.
Original publication
Defining Demographic-specific Coronary Artery Calcium Percentiles in the Population Aged ≥75: The ARIC Study and MESA. Circ Cardiovasc Imaging. Published 1 September 2023. doi:10.
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