Heart failure & cardiomyopathies
Deformation Imaging by Strain in Chronic Heart Failure Over Sacubitril-Valsartan: A Multicenter Echocardiographic Registry
Authors' conclusion
Speckle tracking echocardiography parameters at baseline could be useful to predict LVRR and clinical response to sacubitril-valsartan
Study context
- Population
- Patients with heart failure with reduced ejection fraction (HFrEF) requiring sacubitril/valsartan, 13 Italian centresanalysed
- Participants
- 341 patients
- Exposure
- Early complete response vs Early incomplete response vs No response
- Early complete responsen = 82
- Early incomplete responsen = 55
- No responsen = 204
- Outcome
- Echocardiographic predictors of left ventricular (LV) reverse remodelling (LV end-systolic volume reduction ≥10% and LVEF improvement ≥10%)
- Follow-up
- 6 month
Methodological details13 Italian centres
- 13 Italian centres
Main finding
As reported in the abstract
- Non-ischaemic aetiology, lower left atrial volume index and higher global longitudinal strain (GLS) independent predictors of LVRR (multivariable logistic analysis)
- all P < 0.01
- Baseline GLS < −9.3% associated with early response, AUC
- 0.75, P < 0.0001
Observational data: associations, not effects.
Secondary outcomes
- Left atrial strain best predictor of positive changes in New York Heart Association (NYHA) class and N-terminal pro-brain natriuretic peptide (NT-proBNP)
- all P < 0.05
Original publication
Deformation Imaging by Strain in Chronic Heart Failure Over Sacubitril-Valsartan: A Multicenter Echocardiographic Registry. ESC Heart Fail. Published 29 November 2022. doi:10.
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