Degree of Joint Risk Factor Control and Incident Heart Failure in Hypertensive Patients
Authors' conclusion
The joint risk factor control is associated with a lower risk of incident HF in an accumulative and sex-specific manner.
Study context
- Population
- UK Biobank participants with diagnosed hypertension and matched nonhypertensive controls, followed up until May 31, 2021matched cohort
- Exposure
- Degree of joint risk factor control in hypertensive patients vs nonhypertensive controls
- Hypertensionn = 75,293
- Nonhypertensive controln = 256,619reference
- Outcome
- Incident HF
Methodological detailsmatched
- Matched
Main finding
As reported in the abstract
Incident HF by joint risk factor control (hypertensive patients)
Hazard ratio (95% CI)
Controlling ≥6 risk factors62% lower risk; optimal control, among hypertensive patients
0.38(0.31–0.45)
Hypertension, controlling ≥6 risk factorsvs Nonhypertensive controls
0.79(0.67–0.94)
- Each additional risk factor controlled: lower heart failure (HF) risk
- 20%
Observational data: associations, not effects.
Further findings
Incident HF by sex and medication use (subgroups)
- Protective associations broadly stronger in men than women and in medication users than nonusers
- P for interaction < 0.05
Original publication
Degree of Joint Risk Factor Control and Incident Heart Failure in Hypertensive Patients. JACC Heart Fail. Published 1 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →