Detecting Hemorrhagic Myocardial Infarction With 3.0-T Cardiac Magnetic Resonance (CMR): Insights Into Spatial Manifestation, Time-Dependence, and Optimal Acquisitions
Authors' conclusion
HMI cannot be reliably detected with T1, T2, or T2∗ on 3.0-T CMR immediately after reperfusion. However, T2∗ CMR can be used to diagnose hMI between 24 hours and 7 days postreperfusion. T2 maps at 3.0-T are a strong alternative to T2∗ maps for diagnosing hMI, provided CMR is performed 5 to 7 days postreperfusion. However, diagnosing hMI with T1 is significantly more challenging at 3.0-T compared with both T2∗ and T2.
Study context
- Population
- Canines with reperfused MI; reperfused STEMI patients to establish clinical feasibility20 canines · 50 STEMI patients
- Comparison
- T1, T2 and T2∗ mapping on 3.0-T CMR for detection of hemorrhagic myocardial infarction (hMI)
- Outcome
- Detection of hMI
Methodological detailsanimal model, time-lapse multiparametric mapping, 3.0-T CMR
- Animal model
- Time-lapse multiparametric mapping
- 3.0-T CMR
Performance
As reported in the abstract
| Test or model | T2∗ baseline | T2∗ hMI | AUC vs T2∗ (5 to 7 days) | Sensitivity and specificity | Sensitivity (all time points) |
|---|---|---|---|---|---|
| T2∗ | 27.0 ± 2.4 ms | 11.7 ± 2.8 ms | |||
| T2 | 0.98 | ≥0.95 | |||
| T1 | <0.8 |
T2∗ baseline
T2∗27.0 ± 2.4 ms
T2— not stated in the abstract
T1— not stated in the abstract
T2∗ hMI
T2∗11.7 ± 2.8 ms
T2— not stated in the abstract
T1— not stated in the abstract
AUC vs T2∗ (5 to 7 days)
T2∗— not stated in the abstract
T20.98
T1— not stated in the abstract
Sensitivity and specificity
T2∗— not stated in the abstract
T2≥0.95
T1— not stated in the abstract
Sensitivity (all time points)
T2∗— not stated in the abstract
T2— not stated in the abstract
T1<0.8
- T2∗ hMI vs T2∗ baseline: P < 0.001 — 24 hours to 7 days postreperfusion
Original publication
Detecting Hemorrhagic Myocardial Infarction With 3.0-T CMR: Insights Into Spatial Manifestation, Time-Dependence, and Optimal Acquisitions. JACC Cardiovasc Imaging. Published 8 January 2025. doi:10.
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