Diagnostic accuracy of optical flow ratio: an individual patient-data meta-analysis
Authors' conclusion
This individual patient data meta-analysis demonstrated a high diagnostic accuracy of OFR.
Study context
- Population
- Intermediate coronary stenosis with paired optical flow ratio (OFR) and fractional flow reserve (FFR) assessments, pre- and post-PCI
- Participants
- 574 participants5 studies626 vessels
- Comparison
- OFR vs wire-based FFR
- Outcome
- Vessel-level diagnostic concordance of OFR and FFR (cut-off ≤0.80 for ischaemia; ≤0.90 for suboptimal post-PCI physiology)
Methodological detailsdiagnostic accuracy, 9 international centres
- Diagnostic accuracy
- 9 international centres
Pooled result
As reported in the abstract
Vessel-level diagnostic concordance
| Group | Concordance pre-PCI | Concordance post-PCI | Concordance overall | Sensitivity (overall) | Specificity (overall) | PPV (overall) | NPV (overall) |
|---|---|---|---|---|---|---|---|
| OFR | 91% (95% CI: 88%-94%) | 87% (95% CI: 82%-91%) | 90% (95% CI: 87%-92%) | 84% (95% CI: 79%-88%) | 94% (95% CI: 92%-96%) | 90% (95% CI: 86%-93%) | 89% (95% CI: 86%-92%) |
OFR
Concordance pre-PCI91% (95% CI: 88%-94%)
Concordance post-PCI87% (95% CI: 82%-91%)
Concordance overall90% (95% CI: 87%-92%)
Sensitivity (overall)84% (95% CI: 79%-88%)
Specificity (overall)94% (95% CI: 92%-96%)
PPV (overall)90% (95% CI: 86%-93%)
NPV (overall)89% (95% CI: 86%-92%)
Further pooled results
Predictors of OFR ≥0.10 higher than FFR (multivariate logistic regression)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Low pullback speed | 7.02 (1.68–29.43) | P = 0.008 | |
| 0.050.21520Odds ratio (log scale) |
Predictors of OFR ≥0.10 lower than FFR
| OR (95% CI) | P value | ||
|---|---|---|---|
| Increasing minimal lumen area | 0.39 (0.18–0.82) | P = 0.013 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Diagnostic accuracy of optical flow ratio: an individual patient-data meta-analysis. EuroIntervention. Published 5 June 2023. doi:10.
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