Pulmonary vascular disease & thromboembolism
Differences in Pulmonary Artery Stiffness Measured by CMR in Preterm-Born Young Adults With and Without Bronchopulmonary Dysplasia
Authors' conclusion
Preterm-born young adults with BPD show increased PA stiffness as measured by PWV compared with preterm-born young adults without BPD and at-term-born young adults; RAC was decreased in both preterm-born groups compared with at-term controls. This noninvasive method of measuring PA stiffness might be a valuable tool to identify individuals at risk for early signs of PA hypertension in this population.
Study context
- Population
- Very preterm-born young adults with and without bronchopulmonary dysplasia (BPD), compared with at-term-born young adultsPulse wave velocity (PWV) and relative area change (RAC) measurements could be performed in 57 of 60
- Participants
- 60 adults
- Comparison
- Pulmonary arterial (PA) stiffness (RAC and PWV) in preterm-born young adults with and without BPD compared with at-term-born young adults
- Preterm-born young adults with BPDn = Twenty
- Preterm-born young adults without BPDn = 20
- At-term-born young adultsn = 20
- Outcome
- PWV
Main finding
As reported in the abstract
Preterm-born young adults with BPD vs preterm-born young adults without BPD: P = 0.04 · preterm-born young adults with BPD vs at-term-born young adults: P = 0.04
Further findings
Median
| Outcome | Preterm-born young adults with BPD | Preterm-born young adults without BPD | At-term-born young adults | P value |
|---|---|---|---|---|
| RACPreterm-born young adults with BPD vs at-term-born young adults · RAC decreased with BPD | 62% (IQR 56–82) | 78% (IQR 67–93) | 101% (IQR 87–122) | P < 0.01 |
| RACPreterm-born young adults without BPD vs at-term-born young adults · RAC decreased without BPD | P < 0.01 |
Feasibility of PWV and RAC measurements
- Measurements could be performed
- 57 of 60
Original publication
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