Arrhythmias & electrophysiology
Discordant Treatment Goals for Patients With Atrial Fibrillation and Clinical Trials Metrics
Authors' conclusion
Patients prioritize decreased AF frequency over improvements in severity or duration, and an AFSS ≤5 would be a reasonable outcome of AF treatment. Most patients would consider treatment successful if they had more than 1 AF episode lasting longer than 30 seconds.
Study context
- Population
- Patients receiving active care for atrial fibrillation (AF) at a single tertiary care centreof 7,000 invited (12% response)
- Participants
- 852 patients
- Outcome
- Patient-defined AF treatment priority (frequency, duration or severity) and acceptable AF burden for successful treatment
Methodological detailssurvey, single tertiary care centre, Survey modeled after the Toronto AF Severity Scale (AFSS)
- Survey
- Single tertiary care centre
- Survey modeled after the Toronto AF Severity Scale (AFSS)
Main finding
As reported in the abstract
- Top priority: decrease in episode duration
- 114 (13%)
- Top priority: episode frequency
- 505 (59%)
- Top priority: episode severity
- 230 (27%)
- Success only if never AF again
- 207 (24%)
- Success = fewer AF episodes
- 645 (76%)
- Success only if episodes last less than a few minutes
- 341 (40%)
- Would accept episodes lasting >30 minutes
- 509 (60%)
- AFSS symptom score ≤5 considered a good outcome
- 80%
Observational data: associations, not effects.
Original publication
Discordant Treatment Goals for Patients With Atrial Fibrillation and Clinical Trials Metrics. JACC Clin Electrophysiol. Published 21 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →