Coronary disease & ACSCohort study
E-wave propagation index predicts left ventricular thrombus in patients after ST-elevation myocardial infarction
- cohort study
Authors' conclusion
EPI emerged as significant and independent predictor of LV thrombus formation in STEMI patients. These findings highlight the usefulness of EPI as simple echocardiographic parameter to optimize LV thrombus screening in routine STEMI care.
Study context
- Population
- ST-elevation myocardial infarction (STEMI) patients treated with percutaneous coronary intervention from the MARINA-STEMI studySTEMI patients (17% female), median age 58 [IQR 52–66] years
- Participants
- 665 patients
- Exposure
- EPI against left ventricular (LV) thrombus as assessed by cardiac magnetic resonance imaging (MRI)
- Patients with LV thrombusn = 32
Main finding
As reported in the abstract
EPI · 3 (IQR 2-4) days post-STEMI
Patients with LV thrombus
0.92
those without
1.29
P < 0.001
Observational data: associations, not effects.
Further findings
LV thrombus
| Comparison | adjusted odds ratio (95% CI) | P value | |
|---|---|---|---|
| EPI · EPI independently predicted LV thrombus | 0.84 (0.74–0.95) | P = 0.007 | |
| 0.512Adjusted odds ratio (log scale) |
| Outcome | Values | Estimate | P value |
|---|---|---|---|
| LV thrombus rate by EPI cut-off 0.95 | EPI < 0.95 thrombus rate 15.9% · EPI ≥ 0.95 thrombus rate 2.5% |
- LV thrombus rate by EPI cut-off 0.95: EPI of 0.95 emerged as best cut-off
Discrimination of EPI for LV thrombus
- area under the curve
- 0.73 (95% CI 0.64-0.82, P < 0.001)
Original publication
E-wave propagation index predicts left ventricular thrombus in patients after ST-elevation myocardial infarction. Eur Heart J Acute Cardiovasc Care. Published 13 January 2026. doi:10.1093/ehjacc/zuag004
Summarised from the published abstract; every number is checked against it