Pulmonary vascular disease & thromboembolism
Early versus delayed catheter-based therapies in patients hospitalised with acute pulmonary embolism
Authors' conclusion
Among patients with intermediate- or high-risk PE, early CBT was associated with a lower risk of 90-day death and readmission. A further prospective study on the optimal timing for reperfusion using CBT is needed.
Study context
- Population
- Patients with pulmonary embolism (PE) who underwent catheter-based therapies (CBT) and were included in the Nationwide Readmissions Database1,992 (16.4%) had high-risk PE, 1,856 (15.3%) were treated with delayed CBT
- Participants
- 12,137 patients
- Exposure
- Early CBT vs delayed CBT
- Delayed CBTn = 1,856reference
- Outcome
- Death
- Follow-up
- 90 days
Methodological detailspropensity score weighting (PSW), Nationwide Readmissions Database, January 2017 and December 2020
- Propensity score weighting (PSW)
- Nationwide Readmissions Database
- January 2017 and December 2020
Main finding
As reported in the abstract
early CBT vs delayed CBTHazard ratio (95% CI)
Intermediate-risk PE; lower risk with early CBT
0.55(0.46–0.66)
High-risk PE; lower risk with early CBT
0.89(0.80–0.99)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause readmission · 90 daysEarly CBTvs delayed CBTIntermediate-risk PE; lower rates with early CBT · secondary outcome | 0.86 (0.78–0.95) | |
| All-cause readmission · 90 daysEarly CBTvs delayed CBTHigh-risk PE · secondary outcome | 0.84 (0.69–1.05) | |
| 0.512Hazard ratio (log scale) |
Original publication
Early versus delayed catheter-based therapies in patients hospitalised with acute pulmonary embolism. EuroIntervention. Published 5 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →