Echo-Doppler and strain assessment of filling pressures in adults with congenitally corrected transposition and systemic right ventricles
Authors' conclusion
Despite the complex anatomy, FPs can be assessed non-invasively in adults with sRV without prior systemic tricuspid valve surgery. The current guideline algorithm for diastolic dysfunction in acquired heart disease has limited applicability in this population.
Study context
- Population
- Adults with systemic RV (TGA) without prior systemic tricuspid valve surgery, catheterization and echocardiography within 7 days, 2000–2021
- Participants
- 47 adults
- Exposure
- High vs normal invasive filling pressures: echo-Doppler and strain parameters
- Normaln = 21reference
- Outcome
- Non-invasive (echo-Doppler and strain) assessment of filling pressures
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Echo parameters, high vs normal FP
| Group | Value | Medial e' | Lateral e' | E velocity | Subpulmonic MR velocity | LA reservoir strain | Systemic right ventricle (sRV) GLS | Subpulmonic LV strain |
|---|---|---|---|---|---|---|---|---|
| High filling pressures (FP) | 0.07 ± 0.03 m/s | 0.08 ± 0.04 m/s | 0.9 ± 0.3 m/s | 3.8 ± 1.1 m/s | 18.0 ± 7.6% | −13.0 ± 4.4% | −16.8 ± 5.7% | |
| Normal FP | 44.7% | 0.08 ± 0.03 m/s | 0.08 ± 0.04 m/s | 0.6 ± 0.2 m/s | 2.8 ± 0.9 m/s | 27.9 ± 10.2% | −17.9 ± 5.0% | −23.0 ± 3.8% |
Value
High filling pressures (FP)— not stated in the abstract
Normal FP44.7%
Medial e'
High filling pressures (FP)0.07 ± 0.03 m/s
Normal FP0.08 ± 0.03 m/s
Lateral e'
High filling pressures (FP)0.08 ± 0.04 m/s
Normal FP0.08 ± 0.04 m/s
E velocity
High filling pressures (FP)0.9 ± 0.3 m/s
Normal FP0.6 ± 0.2 m/s
Subpulmonic MR velocity
High filling pressures (FP)3.8 ± 1.1 m/s
Normal FP2.8 ± 0.9 m/s
LA reservoir strain
High filling pressures (FP)18.0 ± 7.6%
Normal FP27.9 ± 10.2%
Systemic right ventricle (sRV) GLS
High filling pressures (FP)−13.0 ± 4.4%
Normal FP−17.9 ± 5.0%
Subpulmonic LV strain
High filling pressures (FP)−16.8 ± 5.7%
Normal FP−23.0 ± 3.8%
- High FP vs Normal FP: P = 0.63 — medial e'
- High FP vs Normal FP: P = 0.88 — lateral e'
- High FP vs Normal FP: P = 0.005 — E velocity
- High FP vs Normal FP: P = 0.004 — subpulmonic MR velocity
- High FP vs Normal FP: P = 0.0009 — LA reservoir strain
- High FP vs Normal FP: P = 0.002 — sRV GLS
- High FP vs Normal FP: P = 0.001 — subpulmonic LV strain
Observational data: associations, not effects.
Further findings
LA size
- LA enlarged
- 83.0%
- Mean indexed LA volume
- 58.3 ± 23.4 mL/m²
Original publication
Echo-Doppler and strain assessment of filling pressures in adults with congenitally corrected transposition and systemic right ventricles. Eur Heart J Cardiovasc Imaging. Published 22 July 2022. doi:10.
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