Effectiveness of Global Registry of Acute Coronary Events (GRACE) risk score in patients admitted to hospital with non-ST elevation acute coronary syndrome (UKGRIS): parallel group cluster randomised controlled trial
Corrected 23 Oct 2026: The two primary outcomes are shown apart: the uptake of guideline-recommended processes with its odds ratio, and the time to the composite cardiac event with its hazard ratio.
Primary result · Use of guideline recommended managementResult — go to the resultOdds ratio 1.16 95% CI 0.70–1.92Authors' conclusion
In adults presenting to hospital with suspected non-ST elevation acute coronary syndrome, the GRS did not improve adherence to guideline recommended management or reduce cardiovascular events at 12 months.
Study context
- Population
- Adults presenting with suspected non-ST elevation ACS to hospitals in England, 2017–201938 UK clusters
- Participants
- 3,050 adults
- Comparison
- GRACE risk score-guided management vs standard care
- GRSn = 1,440
- Standard caren = 1,610reference
- Primary endpoint
- Use of guideline recommended management; time to composite of CV death, non-fatal MI, new onset HF hospital admission and readmission for CV event
- Follow-up
- 12 months
Methodological detailsparallel group
- Parallel group
Primary result
Use of guideline recommended management
Odds ratio
1.16
95% CI 0.70–1.92
P = 0.56
By group
GRSvs Standard care
OR 1.16 (95% CI 0.70–1.92); P = 0.56
As reported in the abstract
Further findings
Duration of hospital admission · within 12 months
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Time to composite of CV death, non-fatal MI, new onset HF hospital admission and readmission for CV eventTime to first composite cardiac event | 0.89 (0.68–1.16) | P = 0.37 | |
| 0.512Hazard ratio (log scale) |
| Outcome | Difference (95% CI) | |
|---|---|---|
| Baseline adjusted EQ-5D-5L utility · 12 months | −0.01 (−0.06 to 0.04) | |
| −0.1−0.0500.05Difference (linear scale) |
Duration of hospital admission · within 12 months
- Similar for GRS and standard care
Original publication
Effectiveness of GRACE risk score in patients admitted to hospital with non-ST elevation acute coronary syndrome (UKGRIS): parallel group cluster randomised controlled trial. BMJ. Published 14 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →