Effects of age on microvascular function in patients with normal coronary arteries
Authors' conclusion
There is an age-dependent physiological increase in minimal microvascular resistance and decrease in microvascular function, which is represented by a decreased MRR and is independent of atherosclerosis.
Study context
- Population
- Patients with angina with no obstructive CAD (ANOCA), microcirculatory function tested by continuous thermodilution305 analysed
- Participants
- 314 patients
- Exposure
- Age groups
- Outcome
- Association of age with microvascular function (resting and hyperaemic Q, Rμ, absolute coronary flow reserve (CFR), MRR)
Main finding
As reported in the abstract
Mean hyperaemic Rμ (Rμ,hyp), ≤52 / 53-64 / ≥65 years: increased significantly with age (R2=0.026)
429±149 WU, 464±164 WU, 503±162 WU
p=0.005
Mean microvascular resistance reserve (MRR), ≤52 / 53-64 / ≥65 years: decreased with age
3.2±1.2, 3.1±1.0, 2.9±0.9
p=0.038
Observational data: associations, not effects.
Further findings
Mean resting Q (Qrest) by age group (≤52, 53-64, ≥65 years)
- Not different in the 3 age groups (R2=0.001)
- 88±34 mL/min, 82±29 mL/min, 86±38 mL/min; p=0.62
Mean resting Rμ (Rμ,rest) by age group (≤52, 53-64, ≥65 years)
- Mean Rμ,rest
- 1,204±460 Wood units (WU), 1,260±411 WU, 1,289±455 WU; p=0.23
Mean hyperaemic Q (Qmax) by age group (≤52, 53-64, ≥65 years)
- Trend towards decreasing Qmax with increasing age (R2=0.010)
- 223±79 mL/min, 209±84 mL/min, 200±80 mL/min; p=0.083
MRR decrease with age, by coronary microvascular dysfunction (CMD) status (subgroup)
- Trend present in patients with CMD (n=121) and without CMD (n=184)
Original publication
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