Effects of supersaturated oxygen therapy on infarct size and microvascular obstruction following myocardial infarction: A systematic review and meta-analysis
Authors' conclusion
SSO₂ therapy significantly reduced infarct size and MVO in patients undergoing PCI for STEMI.
Study context
- Population
- Patients with STEMI undergoing percutaneous coronary intervention (PCI)
- Participants
- 1,660 patients6 studies
- Comparison
- PCI plus SSO₂ vs PCI alone
- PCI plus SSO₂n = 548
- Outcome
- Infarct size and microvascular obstruction (MVO)
Methodological detailsrandom-effects models
- Random-effects models
Pooled result
As reported in the abstract
PCI plus SSO₂ vs PCI aloneEstimate (95% CI)P value
Infarct size
MD −4.31(−6.70 to −1.92)
P < 0.01MVO
SMD −0.72(−1.11 to −0.34)
P < 0.01Further pooled results
Major adverse cardiovascular events (MACE), all-cause mortality, re-infarction, target vessel revascularization (TVR)
- Comparable between the groups
Original publication
Effects of supersaturated oxygen therapy on infarct size and microvascular obstruction following myocardial infarction: A systematic review and meta-analysis. Am Heart J. Published 24 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →