Hypertension, microvascular obstruction and infarct size in patients with STEMI undergoing percutaneous coronary intervention (PCI): Pooled analysis from 7 cardiac magnetic resonance imaging studies
Authors' conclusion
In this large-scale individual patient data pooled analysis, hypertension was not associated with larger IS or MVO after primary PCI for STEMI.
Study context
- Population
- Patients with STEMI undergoing primary PCI with CMR within 1 month after reperfusion
- Participants
- 2,174 patients7 RCTs
- Comparison
- Hypertension vs no hypertension
- Hypertensionn = 1,196
- Outcome
- Microvascular obstruction (MVO) and infarct size (IS) (% LV mass)
Methodological detailsmultivariable adjusted
- Multivariable adjusted
Pooled result
As reported in the abstract
Adjusted difference (95% CI)P value
Between Hypertension and No hypertensionMVO
0.1(−0.3 to 0.6)
P = 0.61Hypertensionvs No hypertensionIS
−0.2(−1.5 to 1.2)
P = 0.80Further pooled results
| Outcome | Estimate | P value | |
|---|---|---|---|
| Death · 1 yearHypertensionvs No hypertensionUnadjusted | HR 2.28 (95% CI 1.44–3.60) | P < 0.001 | |
| Death · 1 yearHypertensionvs No hypertensionMultivariable adjusted | adjusted HR 1.04 (95% CI 0.60–1.79) | P = 0.90 | |
| 0.20.5125Ratio (log scale) |
Original publication
Hypertension, microvascular obstruction and infarct size in patients with STEMI undergoing PCI: Pooled analysis from 7 cardiac magnetic resonance imaging studies. Am Heart J. Published 1 March 2024. doi:10.
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