Impact of intracoronary supersaturated oxygen therapy on microvascular obstruction and infarct size in patients with acute anterior myocardial infarction
Authors' conclusion
SSO2 therapy was associated with significantly reduced microvascular obstruction and FIS in patients with anterior AMI in clinical routine practice.
Study context
- Population
- Patients with anterior AMI after successful primary percutaneous coronary intervention (PCI)20 SSO2 patients and 20 similar non-SSO2 AMI patients
- Participants
- 20 vs 20
- Comparison
- SSO2 vs non-SSO2
- SSO2n = 20
- non-SSO2n = 20
- Outcome
- Baseline characteristics (sex, age, weight, hypertension, dyslipidaemia, smoking, diabetes, prehospital cardiac arrest, door-to-balloon time, TIMI flow, renal function)
Methodological detailsclinical routine practice, multimodal imaging (single-photon emission computed tomography (SPECT), fibroblast activation protein inhibitor positron emission tomography (FAPI-PET), CMR)
- Clinical routine practice
- Multimodal imaging (SPECT, FAPI-PET, CMR)
Main finding
As reported in the abstract
- The two groups did not significantly differ
- p>0.1 for each
Further findings
FIS determined by CMR · lower FIS with SSO2
P < 0.001
FIS determined by SPECT · lower FIS with SSO2
P = 0.014
Myocardial salvage · higher with SSO2
P = 0.002
Microvascular obstruction (MVO)
- MVO occurred less often and was less extreme under SSO2 therapy
Original publication
Impact of intracoronary supersaturated oxygen therapy on microvascular obstruction and infarct size in patients with acute anterior myocardial infarction. EuroIntervention. Published 21 July 2025. doi:10.
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