Arrhythmias & electrophysiology
Efficacy and safety of pulmonary vein isolation with pulsed field ablation vs. novel cryoballoon ablation system for atrial fibrillation
Authors' conclusion
Procedural characteristics were very similar between PFA and CB in regard to procedure duration fluoroscopy time and complications. Atrial fibrillation free survival did not differ between the PFA and CB groups.
Study context
- Population
- Consecutive patients with atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI)
- Participants
- 181 patients
- Exposure
- PVI with pulsed-field ablation (PFA) vs novel cryoballoon (CB) system
- PFAn = 106
- CBn = 75reference
- Outcome
- Procedure, left atrial dwell and fluoroscopic times
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
| Group | Procedure time | Left atrial dwell time | Fluoroscopic time |
|---|---|---|---|
| PFA | 55 (IQR 43-64) | 38 (30-49) | 11 (IQR 9.3-14) |
| CB | 58 (IQR 48-69) | 37 (31-48) | 11 (IQR 8.7-16) |
Procedure time
PFA55 (IQR 43-64)
CB58 (IQR 48-69)
Left atrial dwell time
PFA38 (30-49)
CB37 (31-48)
Fluoroscopic time
PFA11 (IQR 9.3-14)
CB11 (IQR 8.7-16)
- PFA vs CB: P < 0.087 — procedure time
- PFA vs CB: P = 0.871 — left atrial dwell time
- PFA vs CB: P < 0.81 — fluoroscopic time
Observational data: associations, not effects.
Further findings
AF recurrence · median follow-up 404 days (IQR 208-560)
P = 0.406
Safety
| Outcome | PFA | CB |
|---|---|---|
| Procedural complications | ||
| Tamponade | 2 | — not stated in the abstract |
| Temporary ST elevation | 1 | — not stated in the abstract |
| Reversible phrenic nerve palsy | — not stated in the abstract | 3 |
— not stated in the abstract
Original publication
Efficacy and safety of pulmonary vein isolation with pulsed field ablation vs. novel cryoballoon ablation system for atrial fibrillation. Europace. Published 30 November 2023. doi:10.
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