Arrhythmias & electrophysiology
Myocardial Damage, Inflammation, Coagulation, and Platelet Activity During Catheter Ablation Using Radiofrequency and Pulsed-Field Energy
Authors' conclusion
Despite 10 times more myocardial damage, pulsed-field ablation was associated with a similar degree of platelet/coagulation activation, and slightly lower inflammatory response.
Study context
- Population
- Patients with AF indicated for pulmonary vein isolation (PVI)
- Participants
- 65 patients
- Comparison
- Pulsed-field ablation (PFA) vs radiofrequency (RF) ablation for PVI
- PFAn = 33
- RFn = 32reference
- Primary endpoint
- Systemic response: markers of myocardial damage (troponin I), inflammation (interleukin-6), coagulation (D-dimers, fibrin monomers, von Willebrand antigen and factor activity) and platelet activation (P-selectin, activated GpIIb/IIIa antigen)
- Follow-up
- Before procedure, after trans-septal puncture, after LA ablation, and 1 day after
Primary result
As reported in the abstract
Peak troponin release
Further findings
| Outcome | PFA | RF | P value |
|---|---|---|---|
| Procedural time | 55:09 ± 11:57 min | 151:19 ± 41:25 min | P < 0.001 |
| Left atrial dwelling time | 36:00 ± 8:05 min | 115:58 ± 36:49 min | P < 0.001 |
Original publication
Myocardial Damage, Inflammation, Coagulation, and Platelet Activity During Catheter Ablation Using Radiofrequency and Pulsed-Field Energy. JACC Clin Electrophysiol. Published 6 November 2023. doi:10.
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